Hypertension, TLR4 activation in brain and cardiac hypertrophy
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چکیده
منابع مشابه
Hypertension, TLR4 activation in brain and cardiac hypertrophy.
Hypertension or high blood pressure is a major cause of morbidity and mortality around the world. Fortunately, drug therapy along with dietary and lifestyle changes can reduce blood pressure and, therefore, the complications of hypertension in most individuals. On the other hand, untreated or uncontrolled hypertension leads to cerebrovascular accidents, myocardial ischaemia, heart failure, and ...
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Brain renin-angiotensin system (RAS) is significantly involved in the roles of the endocrine RAS in cardiovascular regulation. Our studies indicate that the brain RAS participates in the development of cardiac hypertrophy and fibrosis through sympathetic activation. Inhibition of sympathetic hyperactivity after myocardial infarction through suppression of the brain RAS appears beneficial. Furth...
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Clinical evaluation of the hypertensive patient has traditionally relied on physician measurement of blood pressure and assessment of target-organ involvement by simple laboratory tests. However, this approach is limited in its ability to identify individual patients at high or low risk of complications. In recent years, noninvasive methods have been developed to identify pathological transform...
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The potential involvement of the brain renin-angiotensin system in the hypertension induced by subpressor doses of angiotensin II was tested by the use of newly developed transgenic rats with permanent inhibition of brain angiotensinogen synthesis [TGR(ASrAOGEN)]. Basal systolic blood pressure monitored by telemetry was significantly lower in TGR(ASrAOGEN) than in Sprague-Dawley rats (parent st...
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BACKGROUND Vascular hypertension resulting in increased cardiac load is associated with left ventricular hypertrophy and is a leading predicator for progressive heart disease. The molecular signaling pathways that respond to increases in cardiac load are poorly understood. One potential regulator of the hypertrophic response is the calcium-sensitive phosphatase calcineurin. METHODS AND RESULT...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2014
ISSN: 0008-6363
DOI: 10.1093/cvr/cvu128